Genetic counseling of consanguineous families. Use of Smith's method to calculate recurrence risks in multifactorial inheritance in consanguineous matings.
نویسنده
چکیده
A modification of Smith's method is described for deriving recurrence risks for multifactorial conditions when parents are related. Using cleft palate as an example, the possible increased risks caused by consanguinity are discussed.
منابع مشابه
Genetic counselling of consanguineous fam il es 1 Use of Smith ' s method to calculate
Smith (1971) described a method for deriving the recurrence risk of conditions with multifactorial inheritance in non-consanguineous families. In our paper the method is extended to those cases in which the parents are related. Some results are presented of specific examples in order to give some idea of the increased risk caused by consanguinity in some of the simple cases likely to be met in ...
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ورودعنوان ژورنال:
- Journal of medical genetics
دوره 15 2 شماره
صفحات -
تاریخ انتشار 1978